Publications

 2017

 

Steinhart Z, Pavlovic Z, Chandrashekhar M, Hart T, Wang X, Zhang X, Robitaille
M, Brown KR, Jaksani S, Overmeer R, Boj SF, Adams J, Pan J, Clevers H, Sidhu S,
Moffat J, Angers S. Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling
circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors. Nat Med.
2017 Jan;23(1):60-68. PMID: 27869803

 

2016

 

Gammons MV, Rutherford TJ, Steinhart Z, Angers S, Bienz M. Essential role of
the Dishevelled DEP domain in a Wnt-dependent human-cell-based complementation
assay. J Cell Sci. 2016 Oct 15;129(20):3892-3902. PubMed PMID: 27744318

Lacroix C, Fish I, Torosyan H, Parathaman P, Irwin JJ, Shoichet BK, Angers S.
Identification of Novel Smoothened Ligands Using Structure-Based Docking. PLoS
One. 2016 Aug 4;11(8):e0160365. PubMed PMID: 27490099

Cervenka I, Valnohova J, Bernatik O, Harnos J, Radsetoulal M, Sedova K,
Hanakova K, Potesil D, Sedlackova M, Salasova A, Steinhart Z, Angers S, Schulte
G, Hampl A, Zdrahal Z, Bryja V. Dishevelled is a NEK2 kinase substrate
controlling dynamics of centrosomal linker proteins. Proc Natl Acad Sci U S A.
2016 Aug 16;113(33):9304-9. PubMed PMID: 27486244

Di Sebastiano AR, Fahim S, Dunn HA, Walther C, Ribeiro FM, Cregan SP, Angers
S, Schmid S, Ferguson SS. Role of Spinophilin in Group I Metabotropic Glutamate
Receptor Endocytosis, Signaling, and Synaptic Plasticity. J Biol Chem. 2016 Aug
19;291(34):17602-15. PubMed PMID: 27358397

Daulat AM, Bertucci F, Audebert S, Sergé A, Finetti P, Josselin E, Castellano
R, Birnbaum D, Angers S, Borg JP. PRICKLE1 Contributes to Cancer Cell
Dissemination through Its Interaction with mTORC2. Dev Cell. 2016 May
23;37(4):311-25. PubMed PMID: 27184734.

Farin HF, Jordens I, Mosa MH, Basak O, Korving J, Tauriello DV, de Punder K,
Angers S, Peters PJ, Maurice MM, Clevers H. Visualization of a short-range Wnt
gradient in the intestinal stem-cell niche. Nature. 2016 Feb 18;530(7590):340-3.
PubMed PMID: 26863187.

Chiu CW, Monat C, Robitaille M, Lacomme M, Daulat AM, Macleod G, McNeill H,
Cayouette M, Angers S. SAPCD2 Controls Spindle Orientation and Asymmetric
Divisions by Negatively Regulating the Gαi-LGN-NuMA Ternary Complex. Dev Cell.
2016 Jan 11;36(1):50-62. PubMed PMID: 26766442.

Dey A, Robitaille M, Remke M, Maier C, Malhotra A, Gregorieff A, Wrana JL,
Taylor MD, Angers S, Kenney AM. YB-1 is elevated in medulloblastoma and drives
proliferation in Sonic hedgehog-dependent cerebellar granule neuron progenitor
cells and medulloblastoma cells. Oncogene. 2016 Aug 11;35(32):4256-68. PubMed PMID: 26725322

 

2015

 

Hart T, Chandrashekhar M, Aregger M, Steinhart Z, Brown KR, MacLeod G, Mis M,
Zimmermann M, Fradet-Turcotte A, Sun S, Mero P, Dirks P, Sidhu S, Roth FP,
Rissland OS, Durocher D, Angers S, Moffat J. High-Resolution CRISPR Screens
Reveal Fitness Genes and Genotype-Specific Cancer Liabilities. Cell. 2015 Dec
3;163(6):1515-26. PubMed PMID: 26627737.

Jiang T, McKinley RF, McGill MA, Angers S, Harris TJ. A
Par-1-Par-3-Centrosome Cell Polarity Pathway and Its Tuning for Isotropic Cell
Adhesion. Curr Biol. 2015 Oct 19;25(20):2701-8. PubMed PMID: 26455305.

Han J, Zhang M, Froese S, Dai FF, Robitaille M, Bhattacharjee A, Huang X, Jia
W, Angers S, Wheeler MB, Wei L. The Identification of Novel Protein-Protein
Interactions in Liver that Affect Glucagon Receptor Activity. PLoS One. 2015 Jun
15;10(6):e0129226. PubMed PMID: 26075596;

Khan SM, Min A, Gora S, Houranieh GM, Campden R, Robitaille M, Trieu P,
Pétrin D, Jacobi AM, Behlke MA, Angers S, Hébert TE. Gβ4γ1 as a modulator of M3
muscarinic receptor signalling and novel roles of Gβ1 subunits in the modulation
of cellular signalling. Cell Signal. 2015 Aug;27(8):1597-608.  PubMed PMID: 25916507.

Coyaud E, Mis M, Laurent EM, Dunham WH, Couzens AL, Robitaille M, Gingras AC,
Angers S, Raught B. BioID-based Identification of Skp Cullin F-box (SCF)β-TrCP1/2
E3 Ligase Substrates. Mol Cell Proteomics. 2015 Jul;14(7):1781-95. doi:
10.1074/mcp.M114.045658. PubMed PMID: 25900982; PubMed Central PMCID: PMC4587326.

Raka F, Di Sebastiano AR, Kulhawy SC, Ribeiro FM, Godin CM, Caetano FA,
Angers S, Ferguson SS. Ca(2+)/calmodulin-dependent protein kinase II interacts
with group I metabotropic glutamate and facilitates receptor endocytosis and
ERK1/2 signaling: role of β-amyloid. Mol Brain. 2015 Mar 26;8:21. PubMed PMID: 25885040

Liu J, Lee DM, Yu CG, Angers S, Harris TJ. Stepping stone: a cytohesin
adaptor for membrane cytoskeleton restraint in the syncytial Drosophila embryo.
Mol Biol Cell. 2015 Feb 15;26(4):711-25. PubMed PMID: 25540427

 

Zhulyn O, Nieuwenhuis E, Liu YC, Angers S, Hui CC. Ptch2 shares overlapping
functions with Ptch1 in Smo regulation and limb development. Dev Biol. 2015 Jan
15;397(2):191-202. PubMed PMID: 25448692.

 

Campden R, Pétrin D, Robitaille M, Audet N, Gora S, Angers S, Hébert TE.
Tandem affinity purification to identify cytosolic and nuclear gβγ-interacting
proteins. Methods Mol Biol. 2015;1234:161-84. PubMed PMID: 25304356.

 

 

2014

 

Hurley B, Lee D, Mott A, Wilton M, Liu J, Liu YC, Angers S, Coaker G, Guttman
DS, Desveaux D. The Pseudomonas syringae type III effector HopF2 suppresses
Arabidopsis stomatal immunity. PLoS One. 2014 Dec 11;9(12):e114921. doi:
10.1371/journal.pone.0114921. PubMed PMID: 25503437; PubMed Central PMCID:
PMC4263708.

Liu YC, Couzens AL, Deshwar AR, B McBroom-Cerajewski LD, Zhang X, Puviindran
V, Scott IC, Gingras AC, Hui CC, Angers S. The PPFIA1-PP2A protein complex
promotes trafficking of Kif7 to the ciliary tip and Hedgehog signaling. Sci
Signal. 2014 Dec 9;7(355):ra117. doi: 10.1126/scisignal.2005608. PubMed PMID:
25492966.

 

Zhang M, Robitaille M, Showalter AD, Huang X, Liu Y, Bhattacharjee A, Willard
FS, Han J, Froese S, Wei L, Gaisano HY, Angers S, Sloop KW, Dai FF, Wheeler MB.
Progesterone receptor membrane component 1 is a functional part of the
glucagon-like peptide-1 (GLP-1) receptor complex in pancreatic β cells. Mol Cell
Proteomics. 2014 Nov;13(11):3049-62. doi: 10.1074/mcp.M114.040196. PubMed PMID:
25044020; PubMed Central PMCID: PMC4223491.

Lachance V, Angers S, Parent JL. New insights in the regulation of Rab
GTPases by G protein-coupled receptors. Small GTPases. 2014;5:e29039. doi:
10.4161/sgtp.29039. PubMed PMID: 24950538; PubMed Central PMCID: PMC4205129.

Lachance V, Degrandmaison J, Marois S, Robitaille M, Génier S, Nadeau S,
Angers S, Parent JL. Ubiquitylation and activation of a Rab GTPase is promoted by
a β₂AR-HACE1 complex. J Cell Sci. 2014 Jan 1;127(Pt 1):111-23. doi:
10.1242/jcs.132944. PubMed PMID: 24190883.

 

Li ZJ, Mack SC, Mak TH, Angers S, Taylor MD, Hui CC. Evasion of p53 and G2/M
checkpoints are characteristic of Hh-driven basal cell carcinoma. Oncogene. 2014
May 15;33(20):2674-80. doi: 10.1038/onc.2013.212. PubMed PMID: 23752195.

 

 

2013

 

Roy SJ, Glazkova I, Fréchette L, Iorio-Morin C, Binda C, Pétrin D, Trieu P,
Robitaille M, Angers S, Hébert TE, Parent JL. Novel, gel-free proteomics approach
identifies RNF5 and JAMP as modulators of GPCR stability. Mol Endocrinol. 2013
Aug;27(8):1245-66. doi: 10.1210/me.2013-1091. PubMed PMID: 23798571.

Belotti E, Polanowska J, Daulat AM, Audebert S, Thomé V, Lissitzky JC, Lembo
F, Blibek K, Omi S, Lenfant N, Gangar A, Montcouquiol M, Santoni MJ, Sebbagh M,
Aurrand-Lions M, Angers S, Kodjabachian L, Reboul J, Borg JP. The human PDZome: a
gateway to PSD95-Disc large-zonula occludens (PDZ)-mediated functions. Mol Cell
Proteomics. 2013 Sep;12(9):2587-603. doi: 10.1074/mcp.O112.021022. PubMed PMID:
23722234; PubMed Central PMCID: PMC3769332.

Ahmed SM, Angers S. Emerging non-canonical functions for heterotrimeric G
proteins in cellular signaling. J Recept Signal Transduct Res. 2013
Jun;33(3):177-83. doi: 10.3109/10799893.2013.795972. Review. PubMed PMID:
23721574.

Lam VM, Beerepoot P, Angers S, Salahpour A. A novel assay for measurement of
membrane-protein surface expression using a β-lactamase. Traffic. 2013
Jul;14(7):778-84. doi: 10.1111/tra.12073. PubMed PMID: 23574269.

Hayes M, Naito M, Daulat A, Angers S, Ciruna B. Ptk7 promotes non-canonical
Wnt/PCP-mediated morphogenesis and inhibits Wnt/β-catenin-dependent cell fate
decisions during vertebrate development. Development. 2013 Apr;140(8):1807-18.
doi: 10.1242/dev.090183. Erratum in: Development. 2013 Apr;140(8):1807. PubMed
PMID: 23533179.

 

 

2012

 

Ahmed SM, Thériault BL, Uppalapati M, Chiu CW, Gallie BL, Sidhu SS, Angers S.
KIF14 negatively regulates Rap1a-Radil signaling during breast cancer
progression. J Cell Biol. 2012 Dec 10;199(6):951-67. doi: 10.1083/jcb.201206051.
PubMed PMID: 23209302; PubMed Central PMCID: PMC3518219.

Bao R, Christova T, Song S, Angers S, Yan X, Attisano L. Inhibition of
tankyrases induces Axin stabilization and blocks Wnt signalling in breast cancer
cells. PLoS One. 2012;7(11):e48670. doi: 10.1371/journal.pone.0048670. PubMed
PMID: 23144924; PubMed Central PMCID: PMC3492487.

Liu L, Aerbajinai W, Ahmed SM, Rodgers GP, Angers S, Parent CA. Radil
controls neutrophil adhesion and motility through β2-integrin activation. Mol
Biol Cell. 2012 Dec;23(24):4751-65. doi: 10.1091/mbc.E12-05-0408. PubMed PMID:
23097489; PubMed Central PMCID: PMC3521683.

Lee AH, Hurley B, Felsensteiner C, Yea C, Ckurshumova W, Bartetzko V, Wang
PW, Quach V, Lewis JD, Liu YC, Börnke F, Angers S, Wilde A, Guttman DS, Desveaux
D. A bacterial acetyltransferase destroys plant microtubule networks and blocks
secretion. PLoS Pathog. 2012 Feb;8(2):e1002523. doi:
10.1371/journal.ppat.1002523. PubMed PMID: 22319451; PubMed Central PMCID:
PMC3271077.

Anastas JN, Biechele TL, Robitaille M, Muster J, Allison KH, Angers S, Moon
RT. A protein complex of SCRIB, NOS1AP and VANGL1 regulates cell polarity and
migration, and is associated with breast cancer progression. Oncogene. 2012 Aug
9;31(32):3696-708. doi: 10.1038/onc.2011.528. PubMed PMID: 22179838; PubMed
Central PMCID: PMC3419983.

Daulat AM, Luu O, Sing A, Zhang L, Wrana JL, McNeill H, Winklbauer R, Angers
S. Mink1 regulates β-catenin-independent Wnt signaling via Prickle
phosphorylation. Mol Cell Biol. 2012 Jan;32(1):173-85. doi: 10.1128/MCB.06320-11.
PubMed PMID: 22037766; PubMed Central PMCID: PMC3255712.

 

 

2011

 

Tharmalingam S, Daulat AM, Antflick JE, Ahmed SM, Nemeth EF, Angers S,
Conigrave AD, Hampson DR. Calcium-sensing receptor modulates cell adhesion and
migration via integrins. J Biol Chem. 2011 Nov 25;286(47):40922-33. doi:
10.1074/jbc.M111.265454. PubMed PMID: 21969374; PubMed Central PMCID: PMC3220485.

Ahmed SM, Daulat AM, Angers S. Tandem affinity purification and
identification of heterotrimeric g protein-associated proteins. Methods Mol Biol.
2011;756:357-70. doi: 10.1007/978-1-61779-160-4_22. PubMed PMID: 21870239.

Hui CC, Angers S. Gli proteins in development and disease. Annu Rev Cell Dev
Biol. 2011;27:513-37. doi: 10.1146/annurev-cellbio-092910-154048. Review. PubMed
PMID: 21801010.

Lui TT, Lacroix C, Ahmed SM, Goldenberg SJ, Leach CA, Daulat AM, Angers S.
The ubiquitin-specific protease USP34 regulates axin stability and Wnt/β-catenin
signaling. Mol Cell Biol. 2011 May;31(10):2053-65. doi: 10.1128/MCB.01094-10.
PubMed PMID: 21383061; PubMed Central PMCID: PMC3133363.

 

 

2010

 

Pisterzi LF, Jansma DB, Georgiou J, Woodside MJ, Chou JT, Angers S, Raicu V,
Wells JW. Oligomeric size of the m2 muscarinic receptor in live cells as
determined by quantitative fluorescence resonance energy transfer. J Biol Chem.
2010 May 28;285(22):16723-38. doi: 10.1074/jbc.M109.069443. PubMed PMID:
20304928; PubMed Central PMCID: PMC2878013.

Ahmed SM, Daulat AM, Meunier A, Angers S. G protein betagamma subunits
regulate cell adhesion through Rap1a and its effector Radil. J Biol Chem. 2010
Feb 26;285(9):6538-51. doi: 10.1074/jbc.M109.069948. PubMed PMID: 20048162;
PubMed Central PMCID: PMC2825450.

 

 

2009

 

Fernandez-L A, Northcott PA, Dalton J, Fraga C, Ellison D, Angers S, Taylor
MD, Kenney AM. YAP1 is amplified and up-regulated in hedgehog-associated
medulloblastomas and mediates Sonic hedgehog-driven neural precursor
proliferation. Genes Dev. 2009 Dec 1;23(23):2729-41. doi: 10.1101/gad.1824509.
PubMed PMID: 19952108; PubMed Central PMCID: PMC2788333.

Rose EM, Koo JC, Antflick JE, Ahmed SM, Angers S, Hampson DR. Glutamate
transporter coupling to Na,K-ATPase. J Neurosci. 2009 Jun 24;29(25):8143-55. doi:
10.1523/JNEUROSCI.1081-09.2009. PubMed PMID: 19553454.

Angers S, Moon RT. Proximal events in Wnt signal transduction. Nat Rev Mol
Cell Biol. 2009 Jul;10(7):468-77. doi: 10.1038/nrm2717. Review. PubMed PMID:
19536106.

Louie SH, Yang XY, Conrad WH, Muster J, Angers S, Moon RT, Cheyette BN.
Modulation of the beta-catenin signaling pathway by the dishevelled-associated
protein Hipk1. PLoS One. 2009;4(2):e4310. doi: 10.1371/journal.pone.0004310.
PubMed PMID: 19183803; PubMed Central PMCID: PMC2629544.

 

2008

 

Angers S. Proteomic analyses of protein complexes in the Wnt pathway. Methods
Mol Biol. 2008;468:223-30. doi: 10.1007/978-1-59745-249-6_17. PubMed PMID:
19099258.

Major MB, Roberts BS, Berndt JD, Marine S, Anastas J, Chung N, Ferrer M, Yi
X, Stoick-Cooper CL, von Haller PD, Kategaya L, Chien A, Angers S, MacCoss M,
Cleary MA, Arthur WT, Moon RT. New regulators of Wnt/beta-catenin signaling
revealed by integrative molecular screening. Sci Signal. 2008 Nov 11;1(45):ra12.
doi: 10.1126/scisignal.2000037. PubMed PMID: 19001663.

 

 

2007

 

Angers S. [The tumor suppressor gene WTX, mutated in Wilms tumours, is a
member of the beta-catenin destruction complex]. Med Sci (Paris). 2007
Nov;23(11):1025-7. French. PubMed PMID: 18021721.

Ma AW, Redka DS, Pisterzi LF, Angers S, Wells JW. Recovery of oligomers and
cooperativity when monomers of the M2 muscarinic cholinergic receptor are
reconstituted into phospholipid vesicles. Biochemistry. 2007 Jul
3;46(26):7907-27. PubMed PMID: 17552496.

Major MB, Camp ND, Berndt JD, Yi X, Goldenberg SJ, Hubbert C, Biechele TL,
Gingras AC, Zheng N, Maccoss MJ, Angers S, Moon RT. Wilms tumor suppressor WTX
negatively regulates WNT/beta-catenin signaling. Science. 2007 May
18;316(5827):1043-6. PubMed PMID: 17510365.

Angers S. [KLHL12/Cullin-3 is a new E3 ubiquitin ligase negatively regulating
the Wnt pathway]. Med Sci (Paris). 2007 Mar;23(3):243-4. French. PubMed PMID:
17349278.

 

 

2006

 

Angers S, Li T, Yi X, MacCoss MJ, Moon RT, Zheng N. Molecular architecture
and assembly of the DDB1-CUL4A ubiquitin ligase machinery. Nature. 2006 Oct
5;443(7111):590-3. PubMed PMID: 16964240.

Angers S, Thorpe CJ, Biechele TL, Goldenberg SJ, Zheng N, MacCoss MJ, Moon
RT. The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the
Wnt-beta-catenin pathway by targeting Dishevelled for degradation. Nat Cell Biol.
2006 Apr;8(4):348-57. PubMed PMID: 16547521.

Barbas D, Zappulla JP, Angers S, Bouvier M, Mohamed HA, Byrne JH, Castellucci
VF, DesGroseillers L. An aplysia dopamine1-like receptor: molecular and
functional characterization. J Neurochem. 2006 Jan;96(2):414-27. PubMed PMID:
16336222.

 

 

2004

 

Salahpour A, Angers S, Mercier JF, Lagacé M, Marullo S, Bouvier M.
Homodimerization of the beta2-adrenergic receptor as a prerequisite for cell
surface targeting. J Biol Chem. 2004 Aug 6;279(32):33390-7. PubMed PMID:
15155738.

 

 

2003

 

Azzi M, Charest PG, Angers S, Rousseau G, Kohout T, Bouvier M, Piñeyro G.
Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct
active conformations for G protein-coupled receptors. Proc Natl Acad Sci U S A.
2003 Sep 30;100(20):11406-11. PubMed PMID: 13679574; PubMed Central PMCID:
PMC208770.

 

2002

 

Bertrand L, Parent S, Caron M, Legault M, Joly E, Angers S, Bouvier M, Brown
M, Houle B, Ménard L. The BRET2/arrestin assay in stable recombinant cells: a
platform to screen for compounds that interact with G protein-coupled receptors
(GPCRS). J Recept Signal Transduct Res. 2002 Feb-Nov;22(1-4):533-41. PubMed PMID:
12503639.

Mercier JF, Salahpour A, Angers S, Breit A, Bouvier M. Quantitative
assessment of beta 1- and beta 2-adrenergic receptor homo- and heterodimerization
by bioluminescence resonance energy transfer. J Biol Chem. 2002 Nov
22;277(47):44925-31. PubMed PMID: 12244098.

Issafras H, Angers S, Bulenger S, Blanpain C, Parmentier M, Labbé-Jullié C,
Bouvier M, Marullo S. Constitutive agonist-independent CCR5 oligomerization and
antibody-mediated clustering occurring at physiological levels of receptors. J
Biol Chem. 2002 Sep 20;277(38):34666-73. PubMed PMID: 12089144.

Ayoub MA, Couturier C, Lucas-Meunier E, Angers S, Fossier P, Bouvier M,
Jockers R. Monitoring of ligand-independent dimerization and ligand-induced
conformational changes of melatonin receptors in living cells by bioluminescence
resonance energy transfer. J Biol Chem. 2002 Jun 14;277(24):21522-8. PubMed PMID:
11940583.

Barbas D, Zappulla JP, Angers S, Bouvier M, Castellucci VF, DesGroseillers L.
Functional characterization of a novel serotonin receptor (5-HTap2) expressed in
the CNS of Aplysia californica. J Neurochem. 2002 Jan;80(2):335-45. PubMed PMID:
11902124.

Angers S, Salahpour A, Bouvier M. Dimerization: an emerging concept for G
protein-coupled receptor ontogeny and function. Annu Rev Pharmacol Toxicol.
2002;42:409-35. Review. PubMed PMID: 11807178.

 

 

2001

 

Angers S, Salahpour A, Bouvier M. Biochemical and biophysical demonstration
of GPCR oligomerization in mammalian cells. Life Sci. 2001 Apr
6;68(19-20):2243-50. PubMed PMID: 11358333.

 

 

2000

 

Angers S, Bouvier M. Reply: beyond receptor dimerization. Trends Pharmacol
Sci. 2000 Sep;21(9):326. PubMed PMID: 10973077.

Salahpour A, Angers S, Bouvier M. Functional significance of oligomerization
of G-protein-coupled receptors. Trends Endocrinol Metab. 2000 Jul;11(5):163-8.
Review. PubMed PMID: 10856916.

Morello JP, Salahpour A, Laperrière A, Bernier V, Arthus MF, Lonergan M,
Petäjä-Repo U, Angers S, Morin D, Bichet DG, Bouvier M. Pharmacological
chaperones rescue cell-surface expression and function of misfolded V2
vasopressin receptor mutants. J Clin Invest. 2000 Apr;105(7):887-95. PubMed PMID:
10749568; PubMed Central PMCID: PMC377482.

Angers S, Salahpour A, Joly E, Hilairet S, Chelsky D, Dennis M, Bouvier M.
Detection of beta 2-adrenergic receptor dimerization in living cells using
bioluminescence resonance energy transfer (BRET). Proc Natl Acad Sci U S A. 2000
Mar 28;97(7):3684-9. PubMed PMID: 10725388; PubMed Central PMCID: PMC16300.

 

1999

 

Jockers R, Angers S, Da Silva A, Benaroch P, Strosberg AD, Bouvier M, Marullo
S. Beta(2)-adrenergic receptor down-regulation. Evidence for a pathway that does
not require endocytosis. J Biol Chem. 1999 Oct 8;274(41):28900-8. PubMed PMID:
10506134.